Top seed Federer has a first-round bye in the tournament, which starts on Sunday.
Mitchell is one win away from earning a dream match-up with the 17-time Grand Slam champion at Pat Rafter Arena.
The 34-year-old is the defending champion of the ATP 250 event. He beat Milos Raonic in last year’s final in a three-set final. In 2014, he lost to Lleyton Hewitt in the title clash.
Federer is scheduled to arrive in Brisbane on Saturday morning.
Besides the Swiss maestro, Kei Nishikori, Marin Cilic and Raonic are also taking part in the tournament, before the season opening Grand Slam Australian Open.